Research progress on the role and mechanism of miR-155 in the development of oral squamous cell carcinoma / 口腔疾病防治

@#Oral squamous cell carcinoma (OSCC) is the most common oral cancer. Previous studies have found significantly high miR-155 expression in OSCC. However, the mechanism by which miR-155 plays a role in OSCC oncogenesis is not yet clear. This article reviews the function of the relationship between miR-155 and tumors and the potential role of miR-155 in the development of OSCC. A literature review showed that mir-155, as a small carcinogenic RNA, can inhibit CDC73, BCL6, P27Kip1 and other target genes that play a role in cancer inhibition; promote the proliferation, migration and invasion of OSCC cells; and inhibit apoptosis. miR-155 can also be combined with biological factors (Epstein-Barr virus, human papillomavirus) to promote the development of OSCC.

Observation of the clinical effects of three-flap paltoplasty in preventing anterior palatal fistula / 口腔疾病防治

Objective@#Exploring the effect of three-flap paltoplasty in preventing anterior palatal fistula for patients whose anterior fissures measured more than 0.5 cm.@*Methods@#12 patients aged 18-24 months with unilateral complete cleft palate were selected for the implementation of three-flap paltoplasty for cleft palate repair. Briefly, three-flap paltoplasty is based on the traditional two-flap paltoplasty method and involves the creation of a mucoperiosteal flap A in the contralateral palate in front of the fissure margin that is approximately half the size of the anterior palate. The flap A was sutured to the edge of the contralateral nasal mucosa, and the mucoperior flap of both sides of the loose fissure was sutured in layers, and the suture was removed two weeks after surgery. The recovery of cleft palate was observed. @*Results @#All patients were followed up for 3 months, and 12 patients underwent successful repairs with no fistula and other complications.@*Conclusion@#Three-flap paltoplasty is an effective method of preventing anterior palatal fistula.

Comparing osteogenic effects between concentrated growth factors and the acellular dermal matrix

Abstract Concentrated growth factor (CGF) is an autogenuous product that contains highly concentrated number of platelets and can be derived from venous blood by selective centrifugation. It has been speculated that local growth factors in human platelets (insulinlike growth factor, IGF; transforming growth factor, TGF-b; platelet derived growth factor, PDGF) would enhance healing of grafts and also counteract resorption. The osteogensis effect of CGF and acellular dermal matrix (ADM) for alveolar cleft defects was evaluated in this study. Twenty alveolar cleft patients were divided randomly into two groups. One group underwent guided bone regeneration (GBR) using acellular dermal matrix film combined with alveolar bone grafting using iliac crest bone grafts (GBR group), while the other group underwent alveolar bone grafting combined with CGF (CGF group). Cone beam computed tomography (CBCT) images were obtained at 1 week and 6 months following the procedure. Using Mimics 17.0 software, the bone resorption rate and bone density improvement rate were calculated and compared between the two groups. Although not significant between ADM and CGF in bone resorption rate, the bone density improvement in cases with CGF(61.62 ± 4.728%) was much better than in cases with ADM (27.05 ± 5.607%) (p = 0.0002). Thus, CGF could be recommended to patients with alveolar cleft as a better choice.

Teeth extraction with endotracheal intubation under general anesthesia in special needs patients-a retrospective analysis / 口腔疾病防治

Objective@#To discuss the demand and security of tooth extraction under general anesthesia with endotracheal intubation for the special needs patients.@*Methods@#From January 2014 to December 2015, the cases of tooth extraction under general anesthesia were collected to analyse the demand and security of tooth extraction with general anesthesia.@*Results@#54 patients were recruited in the study in which 11 were with serious limitation of mouth opening, 10 were with serious cardiovascular disease risk, 2 were with history of epilepsy, 13 were with serious dental phobia, and 18 were incoordination patients. All the operations were performed successfully and safely, and all the scores of post anesthetic discharge scoring system exceeded 9 points. No developed complications were showed in 1 day, 1 week, 1 month follow-up.@*Conclusion @#Tooth extraction under general anesthesia with endotracheal intubation is a safe way for special needs patients.